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Everything You Need to Know About Creatine

longevity nutrition Jun 20, 2024
Everything You Need to Know About Creatine

In the realm of sports and fitness, few supplements have garnered as much attention as creatine.

And this is good news if you are over the age of 40, in pursuit of vitality and longevity.

While there is no magic pill to halt time, creatine has shown promise in supporting healthy aging.

Widely recognized for its role in athletic performance, creatine has also gained attention for its potential benefits in combating age-related decline.

In this lesson, you will learn what creatine is, how it works, and why it can be helpful for slowing aging.

You'll also discover the most effective ways to consume creatine and how to get it from the foods you are already eating.

Everything You Need to Know About Creatine

Creatine is a naturally occurring compound found in your body, primarily in muscle tissue.

It plays a crucial role in providing energy to cells, particularly during high-intensity physical activities like resistance training.

Creatine is derived from the amino acids glycine, arginine, and methionine, and is synthesized mainly in the liver and kidneys.

In addition to its endogenous production (meaning it's created inside your cells), creatine can also be obtained through dietary sources such as meat and fish. 

How Creatine Works

Creatine is like a little energy booster for your muscles. 

It works by replenishing adenosine triphosphate (ATP), your body's primary energy currency, which is quickly depleted during intense physical exertion.

When ATP is broken down into adenosine diphosphate (ADP), creatine steps in to donate its phosphate group, allowing ADP to rapidly regenerate into ATP.

This process, known as phosphorylation, ensures a continuous supply of energy for muscle contractions.

There are a few big benefits, especially if you're over the age of 40

  1. Increased ATP production: By donating its phosphate group to adenosine diphosphate (ADP), creatine helps rapidly regenerate ATP. This process, known as phosphorylation, ensures a continuous supply of energy during high-intensity exercise, leading to improved strength, power, and performance.
  2. Enhanced muscle strength and power: Creatine supplementation has consistently demonstrated its ability to increase muscle strength and power output, making it a popular choice among athletes and weightlifters. It allows individuals to train at higher intensities, resulting in improved athletic performance and muscle adaptation. 
  3. Increased muscle mass: Creatine has been shown to promote muscle protein synthesis, leading to an increase in muscle mass over time. This benefit makes it valuable not only for athletes but also for those seeking to slow the loss of muscle and improve body composition (think less fat).
  4. Improved exercise recovery: Creatine supplementation may aid in faster post-exercise recovery by replenishing ATP stores more rapidly. This can help reduce muscle damage, inflammation, and oxidative stress, allowing you to train more frequently and with less downtime between sessions.
  5. Cognitive benefits: Emerging research suggests that creatine may have cognitive-enhancing effects. It is thought to support brain health by improving energy metabolism, increasing brain phosphocreatine levels, and protecting against oxidative stress. These cognitive benefits may include improved memory, attention, and cognitive processing speed.

Different Forms of Creatine Supplementation

  1. Creatine Monohydrate: This is the most widely researched and commonly used form of creatine. It is highly effective, affordable, and well-tolerated by most individuals. Creatine monohydrate is typically available in powder form and is what I use. It can be easily mixed with water or other beverages.
  2. Creatine Hydrochloride (HCl): Creatine HCl is a newer form of creatine that is marketed as having better solubility and absorption. While there is limited research comparing its effectiveness directly with creatine monohydrate, some individuals may find it easier on the digestive system and experience less bloating.
  3. Creatine Ethyl Ester (CEE): CEE is a form of creatine that has been esterified to enhance its absorption. However, research has shown that CEE is less effective at increasing muscle creatine levels compared to creatine monohydrate, making it a less preferred option.
  4. Buffered Creatine: Buffered creatine is a form of creatine that has been combined with alkaline ingredients to reduce stomach acidity and potential side effects. While it may be more tolerable for some individuals, research comparing its effectiveness with creatine monohydrate is limited.

How to Slow Aging with Creatine

Age-related decline is often associated with a reduction in muscle mass, strength, and endurance.

Creatine supplementation has shown promise in addressing these issues, making it an intriguing tool for slowing the aging process.

Here are some ways in which creatine can be beneficial:

  1. Increased muscle strength and power: Aging is often accompanied by a decline in muscle mass and strength, leading to reduced mobility and functionality. Creatine supplementation has been consistently linked to improved muscular strength and power, allowing individuals to maintain an active lifestyle and preserve their independence.
  2. Enhanced cognitive function: Cognitive decline is a common consequence of aging. Creatine has demonstrated neuroprotective properties, such as reducing oxidative stress and promoting energy metabolism in the brain. Studies have suggested that creatine supplementation may improve overall brain health.
  3. Mitochondrial support: Mitochondria are the powerhouse of the cells and are crucial for energy production. Aging is associated with a loss of mitochondrial function, leading to decreased energy production and increased cellular damage. Creatine has been shown to support mitochondrial function, potentially helping to combat age-related decline.

How Much Creatine Should You Take?

To maximize the effectiveness of creatine supplementation, it's essential to follow a few key guidelines:

  1. Dosage: The standard dosage for creatine supplementation is 3-5 grams per day. This dosage has been extensively studied and is considered safe and effective for most individuals. However, consult with a healthcare professional before starting any new supplement regimen.
  2. Loading phase (optional): Some individuals choose to undergo a loading phase, which involves taking higher doses (around 20 grams) of creatine per day for 5-7 days. This approach aims to saturate the muscles with creatine more quickly. However, it is not necessary for everyone, and the benefits of a loading phase are still debated.
  3. Timing: Creatine can be taken at any time of the day, as its effects are cumulative. However, consuming creatine with a meal containing carbohydrates can enhance its absorption by increasing insulin levels, which promotes creatine uptake by muscle cells.
  4. Hydration: Creatine supplementation may cause a temporary increase in water retention within muscle cells. To counteract this effect and maintain optimal hydration, it is essential to drink plenty of water throughout the day.

It May Be Tough to Get Creatine from Your Diet

While creatine supplementation is a convenient and effective method, it is also possible to obtain creatine naturally through diet. Foods such as red meat, poultry, and fish are rich sources of creatine.

Beef, pork, tuna, salmon, and cod all contain between 1.4 to 2.3 grams of creatine per pound. 

Problem is, to get an effective dose of creatine, you need to eat a ton of food, so it's easier to use a creatine monohydrate supplement

For vegetarians and vegans, plant-based alternatives like tempeh and soybeans can provide small amounts of creatine. 

It's worth repeating that dietary sources of creatine may not provide as high of a concentration as supplements do, making supplementation a more reliable option.

Safety Considerations

Creatine is generally regarded as safe for most individuals when taken within recommended dosages.

However, it is important to consider the following safety considerations:

  1. Adequate hydration: Creatine supplementation may cause a temporary increase in water retention within muscle cells. To avoid dehydration and maintain optimal hydration, it is crucial to drink plenty of water throughout the day.
  2. Recommended dosage: The standard dosage for creatine supplementation is 3-5 grams per day. This dosage has been extensively studied and is considered safe for most individuals. However, it is advisable to consult with a healthcare professional before starting any new supplement regimen, particularly for individuals with pre-existing medical conditions.
  3. Quality and purity: When purchasing creatine supplements, it is important to choose reputable brands that adhere to strict quality control standards. Look for products that have been third-party tested for purity and potency.
  4. Individual response: While most individuals tolerate creatine well, some may experience gastrointestinal discomfort, bloating, or muscle cramps. If you experience any adverse effects, it is advisable to discontinue use and consult with a healthcare professional.

Creatine's ability to increase ATP production, improve muscle strength and power, support muscle growth, aid in exercise recovery, and potentially enhance cognitive function makes it a valuable tool for athletes, fitness enthusiasts, and individuals looking to slow aging.

When used responsibly and within recommended dosages, creatine is generally safe and well-tolerated. As with any supplement, it is important to consult with a healthcare professional before starting creatine supplementation, particularly if you have any underlying health conditions.

By incorporating creatine into your fitness and wellness routine, you can tap into its potential benefits and unlock new levels of performance and vitality.


Creatine is a well-researched supplement that offers benefits beyond athletic performance. It increases ATP production, enhances muscle strength and power, promotes muscle growth, aids in exercise recovery, and potentially improves cognitive function. Creatine can be obtained from diet or through supplementation. It is generally safe when taken in recommended dosages, but individuals should stay hydrated and consult healthcare professionals if necessary. Overall, creatine is a valuable tool for individuals seeking optimal health and performance.

To your success,

Coach Joe



Joseph Arangio helps 40+ men and women get leaner, stronger, and happier. He's delivered over 100,000 transformation programs to satisfied clients around the globe. If you want to lose weight from home, with the best online longevity personal trainer, or you want to visit the best age-management personal trainer in the Lehigh Valley, you can take a free 14-day trial.

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